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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are often described as a focus on the practical aspects of study design which include the recruitment process and consent, adhering and the use of routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed different investigators and included participants from different geographical regions. This kind of heterogeneity is essential for pragmatic trials to be valid, and it also helps reduce the chance of bias in the results. However, too much heterogeneity could cause issues with the design of the trial.
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The purpose of pragmatic trials is to mimic real-life scenarios and to achieve maximum credibility externally. Usually, they are requested by practitioners and policymakers in order to guide their decisions. They also provide a useful way to identify the cause-effect relationship between an intervention and its outcomes. However, they should not be used in lieu for the use of explanation studies.
The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the clinical or physiological hypothesis and pragmatic trials, which inform policy and practice decisions. 프라그마틱 슬롯 하는법 suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the traits of a practical study, including the recruitment, design, and delivery of the intervention and follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) resulted in 34 articles, shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to note, however, that the majority were conducted in primary-care settings.